What are Polynucleotides?

Claire Lavery • April 11, 2024

Polynucleotide treatments are one of the newest treatment options available, and they can essentially be viewed as a new variety of injectable treatment. But what are polynucleotides?⁠

What are Polynucleotides?


Polynucleotides play a critical role in anti-ageing, in part due to their ability to retain water, their moisturising capabilities, and their ability to restore the skin. Polynucleotides do more than simply deliver additional hydration to the skin, and as biostimulators, they instead act more like a medicine or food for skin cells, which promotes the production of elastin and collagen.


Polynucleotides are able to connect with a number of different cell receptors and promote a range of reactions, including attracting stem cells to repair and improve the quality of skin tissue. They are also able to tangibly improve the extracellular matrix and have anti-inflammatory properties which protect against free radicals and support an increased number of fibroblasts.


What are Polynucleotides Made From?


Polynucleotides are biopolymers, which are made from fish DNA fragments that have been extracted from trout or salmon sperm due to their resemblance to human DNA.


Ameela Polynucleotides

Ameela is an innovative, non-invasive treatment that uses polynucleotides to restore skin firmness and elasticity whilst also ensuring that the skin is properly protected against free radicals and cellular damage. Ameela also results in improved oxygen and blood vessel supplies as well as the promotion of healthy tissue regeneration.

Ameela Vs. Other Injectable Aesthetic Treatments

Ameela differs from other injectable treatments, such as Profhilo, in that it is a polynucleotide bio-stimulant rather than a hyaluronic based hydrator. Notably, Ameela is proven to prolong the activity of hyaluronic acid by up to 40% and can be used in conjunction with a variety of other aesthetic treatments to further improve outcomes.

Ameela is suitable for all skin types, however, due to its formulation, this treatment is not suitable for those with allergies to fish or shellfish.

Types of Ameela Treatments

Ameela is suitable for a range of treatment areas, including the neck, hands, décolletage, underarms, knees, abdomen, and deep tear trough. There are three different types of Ameela treatment, each of which is formulated with differing concentrations of polynucleotides to provide targeted results for particular treatment areas.

Ameela Eyes works to minimise the appearance of fine lines, wrinkles and eye bags by redensifying the dermo-epidermal tissue in this delicate area. Using a 1.5% concentration of polynucleotides, this formulation promotes the bio-reconstruction of the deep tissues around the eye area to improve superficial wrinkles without the need for fillers and provide a natural, youthful and well-rested appearance.

Ameela Rejuvenation is formulated with a 2% concentration of polynucleotides and uses its unique bio-stimulation process to boost skin elasticity, minimise the appearance of wrinkles and provide noticeable tightening and contouring on the face, neck and décolletage.

Ameela Face/Strong is formulated with a 2.5% concentration of polynucleotides and is designed to treat the jawline and scalp where its stem cell growth promotion abilities can support hair growth. Ameela can also be used to thicken eyebrows when used as a supplementary procedure.

What Can I Expect from My Polynucleotides Treatment

Most clients will benefit from a course of two treatments administered between two and three weeks apart. Following your second treatment, you can look forward to experiencing a 23% reduction in the appearance of fine lines and wrinkles lasting for between six and nine months, after which a top-up treatment can be administered to maintain results for longer.

If you are interested in learning more about Polynucleotides treatment or would like to arrange a consultation to determine whether it is the right treatment for you, please get in touch!


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